Diphen and Depo-testosterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Depo-testosterone (testosterone cypionate). Common drug interactions include dermatitis contact among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Depo-testosterone. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Depo-testosterone?

Depo-testosterone has active ingredients of testosterone cypionate. It is often used in low testosterone. eHealthMe is studying from 4,295 Depo-testosterone users. Check the latest studies of Depo-testosterone.

On Jul, 17, 2026

33 people who take Diphen and Depo-testosterone together, and have interactions are studied.

Diphen and Depo-testosterone drug interactions.

What are the common drug interactions of Diphen and Depo-Testosterone, by gender? *:

female:

Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Sinusitis (inflammation of sinus)
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight increased

male:

Sinusitis (inflammation of sinus)
Nausea (feeling of having an urge to vomit)
Lower respiratory tract infection
Nasopharyngitis (inflammation of the nasopharynx)
Prostatitis (inflammation of the prostate gland)
Vomiting
Acute myocardial infarction (acute heart attack)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Back disorder

What are the common drug interactions of Diphen and Depo-Testosterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Injection site abscess

50-59:

Adverse drug reaction
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood glucose decreased
Cough
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Influenza
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)

60+:

Prostatitis (inflammation of the prostate gland)
Sinusitis (inflammation of sinus)
Colon cancer metastatic (cancer of colon spreads to other part of body)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Hepatic failure (liver failure)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Myalgia (muscle pain)
Nephrolithiasis (calculi in the kidneys)
Pneumonia

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 18 people, 54.55%
Humoral Immune Defect (impairment of humoral immunity): 4 people, 12.12%
Hypersensitivity: 3 people, 9.09%
Combined Immunodeficiency: 3 people, 9.09%
Sleep Disorder: 2 people, 6.06%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 6.06%
Immunodeficiency: 2 people, 6.06%
High Blood Cholesterol: 2 people, 6.06%
Bleeding Disorders: 2 people, 6.06%
Asthma: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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