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Diphen and Divigel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Divigel (estradiol). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Divigel. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Divigel?

Divigel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 894 Divigel users. Check the latest studies of Divigel.

On Jul, 15, 2026

16 people who take Diphen and Divigel together, and have interactions are studied.

Diphen and Divigel drug interactions.

What are the common drug interactions of Diphen and Divigel, by gender? *:

female:

  1. Headache (pain in head)
  2. Arrhythmia (irregular heartbeat)
  3. Fungal infection
  4. Sinusitis (inflammation of sinus)
  5. Chest discomfort
  6. Fatigue (feeling of tiredness)
  7. Nausea (feeling of having an urge to vomit)
  8. Photosensitivity reaction
  9. Rash
  10. Asthma

male:

n/a

What are the common drug interactions of Diphen and Divigel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Abdominal distension
  2. Rash
  3. Skin exfoliation (removal of the oldest dead skin cells)

50-59:

  1. Headache (pain in head)
  2. Sinusitis (inflammation of sinus)
  3. Nasopharyngitis (inflammation of the nasopharynx)
  4. Nausea (feeling of having an urge to vomit)
  5. Photosensitivity reaction
  6. Polyp
  7. Respiratory tract infection
  8. Asthma
  9. Erythema (redness of the skin)
  10. Fatigue (feeling of tiredness)

60+:

n/a

What are the existing conditions these people have? *

  1. Immune System Disorder: 6 people, 37.50%
  2. Arrhythmias (irregular heartbeat): 6 people, 37.50%
  3. Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 3 people, 18.75%
  4. Rashes (redness): 2 people, 12.50%
  5. Pain: 2 people, 12.50%
  6. Lipidosis (disorder of lipid metabolism involving abnormal accumulation of lipids in the reticuloendothelial cells): 2 people, 12.50%
  7. Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 12.50%
  8. Fever: 2 people, 12.50%
  9. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 12.50%
  10. Allergies: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Divigel?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diphen and Divigel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Divigel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diphen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Divigel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and estradiol (the active ingredients of Diphen and Divigel, respectively), and Diphen and Divigel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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