Diphen and Dofetilide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Dofetilide (dofetilide). Common drug interactions include arthralgia among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Dofetilide. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Dofetilide?

Dofetilide has active ingredients of dofetilide. eHealthMe is studying from 2,646 Dofetilide users. Check the latest studies of Dofetilide.

On Aug, 05, 2026

26 people who take Diphen and Dofetilide together, and have interactions are studied.

Diphen and Dofetilide drug interactions.

What are the common drug interactions of Diphen and Dofetilide, by gender? *:

female:

Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Cardiac failure
Cataract (clouding of the lens inside the eye)
Diarrhoea
Pain
Drug hypersensitivity
Muscle spasms (muscle contraction)
Rash

male:

Arrhythmia (irregular heartbeat)
Back pain
Blood pressure increased
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Gait disturbance
Hypertension (high blood pressure)
Lumbar vertebral fracture
Poor venous access
Blood fibrinogen increased
C-reactive protein increased

What are the common drug interactions of Diphen and Dofetilide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Unresponsive to stimuli

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Hypertension (high blood pressure)
Lumbar vertebral fracture
Poor venous access
Blood fibrinogen increased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 34.62%
Multiple Myeloma (cancer of the plasma cells): 7 people, 26.92%
Inflammation: 7 people, 26.92%
Stress And Anxiety: 6 people, 23.08%
Nausea (feeling of having an urge to vomit): 6 people, 23.08%
Hypersensitivity: 6 people, 23.08%
Pain: 5 people, 19.23%
Nausea And Vomiting: 4 people, 15.38%
Diabetes: 4 people, 15.38%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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