Stivarga and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Stivarga (regorafenib) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include fall among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Stivarga and Benadryl. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Stivarga?

Stivarga has active ingredients of regorafenib. eHealthMe is studying from 9,539 Stivarga users. Check the latest studies of Stivarga.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

On Aug, 05, 2026

14 people who take Stivarga and Benadryl together, and have interactions are studied.

Stivarga and Benadryl drug interactions.

What are the common drug interactions of Stivarga and Benadryl, by gender? *:

female:

Fall
Groin pain
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Fatigue (feeling of tiredness)
Diarrhoea
Abdominal pain
Death
Dysphonia (speech disorder attributable to a disorder of phonation)
Blood pressure increased

male:

Fatigue (feeling of tiredness)
Pain in extremity
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Limb discomfort (discomfort in leg)
Peripheral swelling
Anaemia (lack of blood)
Myalgia (muscle pain)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Dysphonia (speech disorder attributable to a disorder of phonation)

What are the common drug interactions of Stivarga and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Back pain
Constipation
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Disease progression
Disturbance in attention
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Groin pain

30-39:

n/a

40-49:

Urinary tract infection
Abdominal discomfort
Abdominal pain upper
Anxiety
Asthenia (weakness)
Bone neoplasm (tumour of bone)
Bone pain
Chest pain
Death
Diarrhoea

50-59:

Pharyngeal ulceration
Rash
Stomatitis (inflammation of mucous membrane of mouth)
Thermal burn (burn by heat)
Tongue discolouration (colour change of tongue)
Tongue ulceration (ulcers on tongue)
Wheezing (a high-pitched whistling sound made while you breath)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain

60+:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Blood pressure fluctuation
Blood pressure inadequately controlled
Blood pressure increased
Decreased appetite
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Gait disturbance
Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)

What are the existing conditions these people have? *

Colon Cancer: 8 people, 57.14%
Rectal Cancer Metastatic (cancer of rectum spreads to other): 2 people, 14.29%
Urinary Tract Infection: 1 person, 7.14%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 7.14%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 7.14%
Bone Pain: 1 person, 7.14%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 7.14%
Cough: 1 person, 7.14%
Dyspnea (difficult or laboured breathing): 1 person, 7.14%
Gastrointestinal Stromal Tumor: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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