Diphen and Durezol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Durezol (difluprednate). Common drug interactions include headache among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Durezol. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

On Jul, 12, 2026

41 people who take Diphen and Durezol together, and have interactions are studied.

What are the common drug interactions of Diphen and Durezol, by gender? *:

female:

Headache (pain in head)
Contusion (a type of hematoma of tissue in which capillaries)
Urinary tract infection
Dysphagia (a condition in which swallowing is difficult or painful)
Nausea (feeling of having an urge to vomit)
Allergy to arthropod sting
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Discomfort
Dry mouth
Dysgeusia (disorder of the sense of taste)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Confusional state
Diarrhoea
Dizziness
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hepatic enzyme increased
Hepatic failure (liver failure)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased

What are the common drug interactions of Diphen and Durezol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bradycardia (abnormally slow heart action)
Cataract (clouding of the lens inside the eye)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Diarrhoea
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Face oedema (swelling of face)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Headache (pain in head)
Allergy to arthropod sting
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Discomfort
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)
Muscle tightness

60+:

Blood pressure increased
Eye pain
Death
Drug dependence
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Left ventricular failure (left ventricle fails to contract forcefully)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pyrexia (fever)
Respiratory depression (respiration has a rate below 12 breaths)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 24.39%
Iridocyclitis (inflammation of the iris and ciliary body of the eye): 6 people, 14.63%
Pemphigoid (tense blisters on the skin): 6 people, 14.63%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 14.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Depression: 3 people, 7.32%
Fever: 3 people, 7.32%
Headache (pain in head): 3 people, 7.32%
High Blood Cholesterol: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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