Diphen and Iclusig drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Iclusig (ponatinib hydrochloride). Common drug interactions include back pain among females and graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Iclusig. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Iclusig?

Iclusig has active ingredients of ponatinib hydrochloride. eHealthMe is studying from 6,109 Iclusig users. Check the latest studies of Iclusig.

On Jul, 08, 2026

13 people who take Diphen and Iclusig together, and have interactions are studied.

What are the common drug interactions of Diphen and Iclusig, by gender? *:

female:

Back pain
Bone pain
Drug ineffective
Dry skin
Headache (pain in head)
Hypersensitivity
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Neck pain

male:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Bk virus infection
Upper respiratory tract infection
Back pain
Blood pressure increased
Bone pain
Drug ineffective
Dry skin
Hyperbilirubinaemia (excess of bilirubin in the blood)
Neoplasm progression (growth of tumour)

What are the common drug interactions of Diphen and Iclusig, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal faeces (abnormal stool)
Arthralgia (joint pain)
Headache (pain in head)

30-39:

Bk virus infection
Blast crisis in myelogenous leukaemia
Bone marrow failure
Cytomegalovirus infection
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
H1n1 influenza (flu (influenza), which is caused by virus influenza a (h1n1))
Herpes simplex (herpes simplex is a common viral infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stem cell transplant

40-49:

Back pain
Bone pain
Dry skin
Blood pressure increased
Drug ineffective
Hyperbilirubinaemia (excess of bilirubin in the blood)
Neoplasm progression (growth of tumour)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Skin wrinkling (wrinkle on skin)

50-59:

Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Ejection fraction decreased (systolic heart failure)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Rash erythematous (redness of the skin)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

60+:

Arthritis fungal (inflammation of a joint by a fungus)
Fungal rhinitis (infection of the mucous membrane inside the nose due to fungus)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 10 people, 76.92%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 15.38%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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