Entyvio and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entyvio (vedolizumab) and Protonix (pantoprazole sodium). Common drug interactions include pustular psoriasis among females and bronchial hyperreactivity among males.

The phase IV clinical study analyzes what interactions people have when they take Entyvio and Protonix. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Entyvio?

Entyvio has active ingredients of vedolizumab. It is often used in crohn's disease. eHealthMe is studying from 23,827 Entyvio users. Check the latest studies of Entyvio.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 08, 2026

83 people who take Entyvio and Protonix together, and have interactions are studied.

What are the common drug interactions of Entyvio and Protonix, by gender? *:

female:

Pustular psoriasis (raised bumps on the skin that are filled with pus)
Rash pustular (redness with pustules)
Renal disorder (kidney disease)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Small intestinal obstruction (blockage in small intestine)
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Viral infection
Cystitis (inflammation of the wall of the bladder)
Ear infection
Gastrointestinal inflammation (inflammation of stomach and intestine)

male:

Bronchial hyperreactivity
Respiratory syncytial virus infection (viral disease of respiratory system)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Prostatitis (inflammation of the prostate gland)
Road traffic accident
Sinusitis (inflammation of sinus)
Pertussis (whooping cough: a disease of the respiratory mucous membrane)
Status asthmaticus (a asthma attack not responds to regular medicines)
Abdominal pain upper
Adverse drug reaction

What are the common drug interactions of Entyvio and Protonix, by age (0-1 to 60+)? *:

0-1:

Anal stenosis (narrowing of the anal sphincter and opening)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

Pertussis (whooping cough: a disease of the respiratory mucous membrane)
Respiratory failure (inadequate gas exchange by the respiratory system)
Status asthmaticus (a asthma attack not responds to regular medicines)
Agitation (state of anxiety or nervous excitement)
Arthritis enteropathic (form of chronic, inflammatory arthritis associated with the occurrence of an inflammatory bowel disease)
Insomnia (sleeplessness)
Septic shock (shock due to blood infection)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Substance-induced psychotic disorder

20-29:

Small intestinal obstruction (blockage in small intestine)
Abscess (pus)
Blood iron decreased
Brain neoplasm (tumour of brain)
Cardiac disorder
Cerebral haemorrhage (bleeding within the brain)
Clavicle fracture
Coagulopathy (blood's ability to clot is impaired)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)

30-39:

Foetal death (death of foetus)
Pregnancy
Sinusitis (inflammation of sinus)

40-49:

Confusional state
Diarrhoea
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Heart rate increased
Hepatic steatosis (fatty liver disease)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Infusion related reaction

50-59:

Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pruritus (severe itching of the skin)
Vomiting
Abdominal pain
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Back pain

60+:

Addison's disease (addison's disease, a hormonal disorder disease)
Arthralgia (joint pain)
Mycobacterium avium complex infection
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Pain in extremity
Pneumonia
Rales (an abnormal respiratory sound characterized by fine crackles)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 19 people, 22.89%
Nausea (feeling of having an urge to vomit): 18 people, 21.69%
High Blood Pressure: 18 people, 21.69%
Depression: 16 people, 19.28%
High Blood Cholesterol: 13 people, 15.66%
Seasonal Allergy (allergic condition due to certain season): 10 people, 12.05%
Inflammation: 9 people, 10.84%
Abdominal Pain: 9 people, 10.84%
Asthma: 8 people, 9.64%
Stress And Anxiety: 6 people, 7.23%

* Approximation only. Some reports may have incomplete information.

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