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Diphen and Savaysa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Savaysa (edoxaban tosylate). Common drug interactions include neck pain among females.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Savaysa. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,430 Diphen users. Check the latest studies of Diphen.

What is Savaysa?

Savaysa has active ingredients of edoxaban tosylate. eHealthMe is studying from 966 Savaysa users. Check the latest studies of Savaysa.

On Jan, 23, 2026

13 people who take Diphen and Savaysa together, and have interactions are studied.

Diphen and Savaysa drug interactions.

What are the common drug interactions of Diphen and Savaysa, by gender? *:

female:

  1. Neck pain
  2. Chest injury
  3. Hip fracture
  4. Multiple allergies (allergy to multiple agents)
  5. Pneumonia
  6. Pulmonary thrombosis (scarring in the lungs)
  7. Thrombosis (formation of a blood clot inside a blood vessel)
  8. Pruritus (severe itching of the skin)
  9. Headache (pain in head)
  10. Neoplasm (tumour)

male:

n/a

What are the common drug interactions of Diphen and Savaysa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Pneumonia
  2. Pulmonary thrombosis (scarring in the lungs)
  3. Thrombosis (formation of a blood clot inside a blood vessel)
  4. Neoplasm (tumour)
  5. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Pneumonia bacterial (pneumonia associated with bacterial infection)
  8. Post procedural infection
  9. Respiratory tract infection bacterial
  10. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 9 people, 69.23%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Savaysa?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diphen and Savaysa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Savaysa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diphen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Savaysa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and edoxaban tosylate (the active ingredients of Diphen and Savaysa, respectively), and Diphen and Savaysa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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