Diphenoxylate hydrochloride and atropine sulfate and Ondansetron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphenoxylate hydrochloride and atropine sulfate (atropine sulfate; diphenoxylate hydrochloride) and Ondansetron (ondansetron). Common drug interactions include gingival disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Diphenoxylate hydrochloride and atropine sulfate and Ondansetron. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Diphenoxylate hydrochloride and atropine sulfate?

Diphenoxylate hydrochloride and atropine sulfate has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 335 Diphenoxylate hydrochloride and atropine sulfate users. Check the latest studies of Diphenoxylate hydrochloride and atropine sulfate.

What is Ondansetron?

Ondansetron has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 122,738 Ondansetron users. Check the latest studies of Ondansetron.

On Jul, 30, 2026

34 people who take Diphenoxylate hydrochloride and atropine sulfate and Ondansetron together, and have interactions are studied.

Diphenoxylate hydrochloride and atropine sulfate and Ondansetron drug interactions.

What are the common drug interactions of Diphenoxylate Hydrochloride And Atropine Sulfate and Ondansetron, by gender? *:

female:

Gingival disorder (gum disease)
Haemorrhage (bleeding)
Hospitalisation
Lethargy (tiredness)
Lipase increased
Liver abscess (pus in liver)
Loss of consciousness
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myopia (difficult to see objects that are far away)
Ocular hypertension (intraocular pressure higher than normal)

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain in extremity
Blood creatinine increased
Cardiac failure congestive
Constipation
Intestinal perforation (complete penetration of the wall of the intestine)
Ammonia increased
Blood alkaline phosphatase increased
Blood potassium increased

What are the common drug interactions of Diphenoxylate Hydrochloride And Atropine Sulfate and Ondansetron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Heart rate increased
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
International normalised ratio increased
Metastases to liver (cancer spreads to liver)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

40-49:

n/a

50-59:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Back pain
Bone density decreased
Depression
Neck pain
Osteoporosis (bones weak and more likely to break)

60+:

Muscle spasms (muscle contraction)
Cystitis (inflammation of the wall of the bladder)
Intestinal perforation (complete penetration of the wall of the intestine)
Kidney infection
Nasopharyngitis (inflammation of the nasopharynx)
Urinary tract infection
Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Feeling hot

What are the existing conditions these people have? *

Pain: 10 people, 29.41%
Stress And Anxiety: 6 people, 17.65%
High Blood Pressure: 6 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.71%
Multiple Myeloma (cancer of the plasma cells): 5 people, 14.71%
Hiv Infection: 4 people, 11.76%
Insomnia (sleeplessness): 4 people, 11.76%
Depression: 4 people, 11.76%
High Blood Cholesterol: 4 people, 11.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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