Divalproex sodium and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include major depression among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Adderall. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

On Jul, 12, 2026

97 people who take Divalproex sodium and Adderall together, and have interactions are studied.

Divalproex sodium and Adderall drug interactions.

What are the common drug interactions of Divalproex Sodium and Adderall, by gender? *:

female:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Nasopharyngitis (inflammation of the nasopharynx)
Neuralgia (pain in one or more nerves)
Pneumonia
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
White blood cell count increased
Pain in extremity
Asthma

male:

Anxiety
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Peripheral coldness
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain
Blood iron decreased
Blood pressure decreased
Drug dependence

What are the common drug interactions of Divalproex Sodium and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Anger
Hospitalisation
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Weight decreased
Ammonia increased
Granulocytopenia (lack of granulocyte)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)

20-29:

Arthralgia (joint pain)
Back pain
Burning sensation
Joint swelling
Limb discomfort (discomfort in leg)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Chest pain
Decreased appetite
Dependence
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

30-39:

Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gestational diabetes (diabetes in pregnancy)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abnormal behaviour
Affective disorder (mental disorder)
Anger
Anxiety
Cerebrovascular stenosis (narrowing of brain blood vessels)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Drug dependence
Drug ineffective

50-59:

Pain in extremity
Peripheral swelling
Rash
Anxiety
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Drug dependence
Head injury
Oral herpes (viral infection of mouth)
Spinal decompression (relief of pressure on one or many pinched nerves (neural impingement) of the spinal column)

60+:

Cataract (clouding of the lens inside the eye)
Cough
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Chronic kidney disease
Decreased activity
Drug ineffective
Emotional distress

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 69 people, 71.13%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 45 people, 46.39%
Depression: 9 people, 9.28%
Drowsiness: 8 people, 8.25%
Migraine (headache): 6 people, 6.19%
Bipolar Disorder (mood disorder): 6 people, 6.19%

* Approximation only. Some reports may have incomplete information.

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