Divalproex sodium and Biktarvy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Biktarvy (bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate). Common drug interactions include pain among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Biktarvy. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Biktarvy?

Biktarvy has active ingredients of bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 19,543 Biktarvy users. Check the latest studies of Biktarvy.

On Jul, 28, 2026

21 people who take Divalproex sodium and Biktarvy together, and have interactions are studied.

Divalproex sodium and Biktarvy drug interactions.

What are the common drug interactions of Divalproex Sodium and Biktarvy, by gender? *:

female:

Pain
Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood creatinine increased
Emotional distress
Osteoporosis (bones weak and more likely to break)
Chronic kidney disease
Back pain
Depression
Liver disorder (liver diseases)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Glomerulonephritis membranous (nephritis with inflammation of the capillary loops in the renal glomeruli)
Lower limb fracture
Osteonecrosis (death of bone)
Tooth loss
Decreased activity
Depression
Fatigue (feeling of tiredness)

What are the common drug interactions of Divalproex Sodium and Biktarvy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Hand fracture
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Rib fracture

40-49:

Pain
Anxiety
Blood creatinine increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Emotional distress
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Depression
Liver disorder (liver diseases)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Chronic kidney disease
Renal failure (kidney dysfunction)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Glomerulonephritis membranous (nephritis with inflammation of the capillary loops in the renal glomeruli)
Lower limb fracture
Osteonecrosis (death of bone)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Pain
Pain in extremity
Pain in jaw
Quality of life decreased
Rib fracture
Spinal fracture (fracture in one of vertebrae)
Arthralgia (joint pain)
Back pain

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 23.81%
Stress And Anxiety: 3 people, 14.29%
Pain: 3 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
Depression: 3 people, 14.29%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 9.52%
Muscle Spasms (muscle contraction): 2 people, 9.52%
Insomnia (sleeplessness): 2 people, 9.52%
High Blood Pressure: 2 people, 9.52%
Bipolar Disorder (mood disorder): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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