Divalproex sodium and Chlorthalidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Chlorthalidone (chlorthalidone). Common drug interactions include nausea among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Chlorthalidone. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Chlorthalidone?

Chlorthalidone has active ingredients of chlorthalidone. It is often used in high blood pressure. eHealthMe is studying from 12,482 Chlorthalidone users. Check the latest studies of Chlorthalidone.

On Jul, 18, 2026

34 people who take Divalproex sodium and Chlorthalidone together, and have interactions are studied.

Divalproex sodium and Chlorthalidone drug interactions.

What are the common drug interactions of Divalproex Sodium and Chlorthalidone, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Renal injury (kidney injury)
Swelling face
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypersensitivity
Impaired healing
Pain
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)

male:

Sinusitis (inflammation of sinus)
Cataract (clouding of the lens inside the eye)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Type 1 diabetes mellitus
Ulcer haemorrhage (bleeding ulcer)
Blood glucose decreased
Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Anxiety
Contusion (a type of hematoma of tissue in which capillaries)

What are the common drug interactions of Divalproex Sodium and Chlorthalidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dysstasia (difficulty in standing)
Emotional distress
Gait disturbance
Pain
Renal injury (kidney injury)
Surgery

50-59:

Arthralgia (joint pain)
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder
Chest discomfort
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

White blood cell count increased
Cataract (clouding of the lens inside the eye)
Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 14.71%
Stiff Person Syndrome: 4 people, 11.76%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 4 people, 11.76%
Hiv Infection: 3 people, 8.82%
Drowsiness: 3 people, 8.82%
Cough: 3 people, 8.82%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.82%
Renal Cell Carcinoma (a kidney cancer): 2 people, 5.88%
Primary Immunodeficiency Syndrome: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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