Divalproex sodium and Midazolam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Midazolam (midazolam). Common drug interactions include drug ineffective among females and hyperammonaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Midazolam. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Midazolam?

Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.

On Jul, 17, 2026

42 people who take Divalproex sodium and Midazolam together, and have interactions are studied.

Divalproex sodium and Midazolam drug interactions.

What are the common drug interactions of Divalproex Sodium and Midazolam, by gender? *:

female:

Drug ineffective
Abnormal behaviour
Aggression
Blood calcium decreased
Bradyarrhythmia (heart slowness)
Disease recurrence
Electrocardiogram qt prolonged
Flushing (the warm, red condition of human skin)
Maternal exposure during pregnancy (use of substance during pregnancy)
Mood swings (an extreme or rapid change in mood)

male:

Hyperammonaemia
Hypertransaminasaemia
Irritability
Memory impairment
Mood swings (an extreme or rapid change in mood)
Negative thoughts
Pancreatitis (inflammation of pancreas)
Pneumonia
Soliloquy
Coma (state of unconsciousness lasting more than six hours)

What are the common drug interactions of Divalproex Sodium and Midazolam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Delirium (wild excitement)
Hepatic enzyme increased
Pancreatitis (inflammation of pancreas)

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Mood swings (an extreme or rapid change in mood)
Confusional state
Infusion site pain
Irritability
Lethargy (tiredness)
Memory impairment
Negative thoughts
Soliloquy
Abdominal pain

20-29:

Anticonvulsant drug level increased
Ataxia (loss of full control of bodily movements)
Blood calcium decreased
Diplopia (double vision)
Disease recurrence
Dysarthria (speech disorder)
Lethargy (tiredness)

30-39:

Hemiparesis (weakness on one side of the body)
Facial paralysis (loss of function of face muscle)
Overdose
Drug level above therapeutic
Maternal exposure during pregnancy (use of substance during pregnancy)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

40-49:

Coma (state of unconsciousness lasting more than six hours)
Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Respiratory alkalosis (elevated blood ph due to excess breathing)
Dermatitis exfoliative generalised (inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface)
Drug ineffective

50-59:

Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Trichosporon infection (a fungal infection by trichophyton)
Hyperammonaemia
Hypertransaminasaemia
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Lymphocyte count decreased
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Drug ineffective
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Bradyarrhythmia (heart slowness)
Electrocardiogram qt prolonged

What are the existing conditions these people have? *

Neuralgia (pain in one or more nerves): 15 people, 35.71%
High Blood Pressure: 15 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 35.71%
Headache (pain in head): 13 people, 30.95%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 21.43%
Local Anaesthesia: 8 people, 19.05%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 3 people, 7.14%
Pneumonia: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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