Divalproex sodium and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include atrial fibrillation among females and injury among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Vicodin. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 19, 2026

71 people who take Divalproex sodium and Vicodin together, and have interactions are studied.

Divalproex sodium and Vicodin drug interactions.

What are the common drug interactions of Divalproex Sodium and Vicodin, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fall
Urinary tract infection
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiac disorder
Cellulitis (infection under the skin)
Femur fracture
Foot fracture
Hordeolum (small collection of pus (abscess) on the eyelid)
Seasonal allergy (allergic condition due to certain season)

male:

Injury
Osteomyelitis (infection of bone)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiomegaly (increased size of heart than normal)
Fatigue (feeling of tiredness)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Haemorrhage (bleeding)
Hot flush (sudden feelings of heat)
Infection
Loose tooth

What are the common drug interactions of Divalproex Sodium and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Abdominal pain upper
Blood glucose increased
Cholecystitis chronic (long lasting infection of gallbladder)
Colitis (inflammation of colon)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gallbladder disorder
Injury
Insomnia (sleeplessness)
Migraine (headache)

40-49:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Pulmonary embolism (blockage of the main artery of the lung)
Weakness
Respiratory disorder (respiratory disease)
Arthralgia (joint pain)
Drug dependence
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Dyspnoea (difficult or laboured respiration)

50-59:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Balance disorder
Bone density decreased
Chest discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

60+:

Infection
Injury
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiomegaly (increased size of heart than normal)
Fatigue (feeling of tiredness)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Haemorrhage (bleeding)
Hot flush (sudden feelings of heat)
Loose tooth
Lymphadenopathy (disease or enlargement of lymph nodes)

What are the existing conditions these people have? *

Prostate Cancer: 13 people, 18.31%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.86%
Nausea (feeling of having an urge to vomit): 6 people, 8.45%
Cough: 6 people, 8.45%
Multiple Myeloma (cancer of the plasma cells): 5 people, 7.04%
Immunodeficiency Common Variable: 5 people, 7.04%
High Blood Pressure: 5 people, 7.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.04%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 7.04%
Stiff Person Syndrome: 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

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