Ritalin and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Amaryl (glimepiride). Common drug interactions include somnolence among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Amaryl. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

On Jul, 19, 2026

50 people who take Ritalin and Amaryl together, and have interactions are studied.

What are the common drug interactions of Ritalin and Amaryl, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal distension
Alopecia (absence of hair from areas of the body)
Application site reaction
Arthropathy
Asthenia (weakness)
Bladder cancer
Blood cholesterol increased
Blood iron decreased
Cardiac failure congestive

male:

Pneumonia
Anaemia (lack of blood)
Purpura (purplish discoloration of the skin)
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Transaminases decreased
Blood cholesterol increased
Blood triglycerides increased
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haemorrhage (bleeding)

What are the common drug interactions of Ritalin and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Arthralgia (joint pain)
Arthropathy
Back pain
Cough
Cystitis (inflammation of the wall of the bladder)
Decreased appetite
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dyspnoea (difficult or laboured respiration)

50-59:

Mitral valve disease (disease of mitral valve of heart)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Fatigue (feeling of tiredness)
Purpura (purplish discoloration of the skin)
Application site reaction
Asthenia (weakness)
Blood cholesterol increased
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis (inflammation of colon)
Colon cancer
Death

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 32.00%
High Blood Pressure: 6 people, 12.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 12.00%
Depression: 5 people, 10.00%
Type 2 Diabetes: 4 people, 8.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.00%
Osteoporosis (bones weak and more likely to break): 3 people, 6.00%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.00%
Constipation: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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