Divalproex sodium and Vimpat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Vimpat (lacosamide). Common drug interactions include myocardial infarction among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Vimpat. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Vimpat?

Vimpat has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 20,831 Vimpat users. Check the latest studies of Vimpat.

On Jul, 17, 2026

83 people who take Divalproex sodium and Vimpat together, and have interactions are studied.

Divalproex sodium and Vimpat drug interactions.

What are the common drug interactions of Divalproex Sodium and Vimpat, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oxygen saturation decreased
Pain
Rash
Rash pruritic (redness with itching)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tendon rupture (tear of tendon)
Upper limb fracture
Alopecia (absence of hair from areas of the body)

male:

Hallucination (an experience involving the perception of something not present)
Fall
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscular weakness (muscle weakness)
Aggression
Limb injury
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood cholesterol increased
Blood pressure increased

What are the common drug interactions of Divalproex Sodium and Vimpat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Oxygen saturation decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Multiple-drug resistance

10-19:

Agitation (state of anxiety or nervous excitement)
Anger
Hospitalisation
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Back pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Death
Renal failure (kidney dysfunction)

20-29:

Nausea (feeling of having an urge to vomit)
Vomiting
Head banging (violently shaking the head in time with the music)
Self injurious behaviour
Seizure cluster (small group of seizure)

30-39:

Diarrhoea
Headache (pain in head)
Pruritus (severe itching of the skin)
Sedation
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Headache (pain in head)
Hypersomnia (excessive daytime sleepiness (eds))
Laziness
Muscle atrophy (a decrease in the mass of the muscle)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pigmentation disorder (disturbances of human skin colour)
Weight decreased
Fatigue (feeling of tiredness)
Cardiac arrest
Chronic kidney disease

50-59:

Fall
Muscular weakness (muscle weakness)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Injection site inflammation
Injection site irritation
Injection site rash
Memory impairment
Muscle spasms (muscle contraction)
Palpitations (feelings or sensations that your heart is pounding or racing)

60+:

Hallucination (an experience involving the perception of something not present)
Dizziness
Chills (felling of cold)
Death
Decreased appetite
Disease progression
Eye irritation
Fall
Full blood count decreased
Haemoglobin decreased

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 26 people, 31.33%
Stress And Anxiety: 6 people, 7.23%
Muscle Spasms (muscle contraction): 6 people, 7.23%
Bipolar Disorder (mood disorder): 6 people, 7.23%
Asthma: 6 people, 7.23%
Sleep Disorder: 5 people, 6.02%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.02%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.02%
High Blood Pressure: 5 people, 6.02%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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