Divalproex sodium and Vitamin e drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Vitamin e (tocopherols and tocotrienols). Common drug interactions include drug level increased among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Vitamin e. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

67 people who take Divalproex sodium and Vitamin e together, and have interactions are studied.

Divalproex sodium and Vitamin e drug interactions.

What are the common drug interactions of Divalproex Sodium and Vitamin E, by gender? *:

female:

Drug level increased
Dysstasia (difficulty in standing)
Electrocardiogram qt prolonged
Limb injury
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Oxygen saturation decreased
Pelvic fracture
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Streptococcal infection
Tooth abscess (pus formation in tooth)

male:

Insomnia (sleeplessness)
Drug ineffective
Blood triglycerides increased
Blood urea increased
Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Dyskinesia (abnormality or impairment of voluntary movement)
Gamma-glutamyltransferase increased
Glomerular filtration rate decreased
Haematocrit decreased
Haemoglobin decreased

What are the common drug interactions of Divalproex Sodium and Vitamin E, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest pain
Hallucination, auditory (perceiving sounds without auditory stimulus)
Suicidal ideation
Suicide attempt
Syncope (loss of consciousness with an inability to maintain postural tone)
Trichomoniasis (a sexually transmitted disease caused by a parasite)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Depression
Family stress
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

30-39:

Cataract (clouding of the lens inside the eye)

40-49:

Hallucination (an experience involving the perception of something not present)
Insomnia (sleeplessness)

50-59:

Weight decreased
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Activated partial thromboplastin time prolonged
Decreased appetite
Drug ineffective
Femur fracture
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)
Head injury

60+:

Urinary tract infection
Fall
Asthenia (weakness)
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Diarrhoea
Pain in extremity
Arthralgia (joint pain)
Blood pressure decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 20 people, 29.85%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 9 people, 13.43%
Pain: 8 people, 11.94%
Neuropathy Peripheral (surface nerve damage): 6 people, 8.96%
Insomnia (sleeplessness): 6 people, 8.96%
Rashes (redness): 5 people, 7.46%
Fever: 5 people, 7.46%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 7.46%
Allergies: 5 people, 7.46%
Abdominal Discomfort: 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex sodium and Vitamin e?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously