Divalproex and Bumetanide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Bumetanide (bumetanide). Common drug interactions include neck pain among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Bumetanide. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Bumetanide?

Bumetanide has active ingredients of bumetanide. It is often used in fluid retention. eHealthMe is studying from 20,532 Bumetanide users. Check the latest studies of Bumetanide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

43 people who take Divalproex and Bumetanide together, and have interactions are studied.

Divalproex and Bumetanide drug interactions.

What are the common drug interactions of Divalproex and Bumetanide, by gender? *:

female:

Neck pain
Neuralgia (pain in one or more nerves)
Neutropenia (an abnormally low number of neutrophils)
Oedema peripheral (superficial swelling)
Oxygen saturation decreased
Pain
Pain in extremity
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Pericarditis (inflammation of the pericardium)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)

male:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Decreased appetite
Dementia (madness)
Device dislocation
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the common drug interactions of Divalproex and Bumetanide, by age (0-1 to 60+)? *:

0-1:

Bedridden
Hypophagia (reduced food intake)
Respiratory disorder (respiratory disease)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity
Fear
Hallucination, visual (seeing things that aren't there)

40-49:

Chest discomfort
Nausea (feeling of having an urge to vomit)
Allergy to chemicals
Cardiac failure acute
Dehydration (dryness resulting from the removal of water)
Dizziness
Flushing (the warm, red condition of human skin)
Hypokalaemia (low potassium)
Irritable bowel syndrome
Memory impairment

50-59:

Suicidal ideation
Chronic kidney disease
Gastric ulcer (stomach ulcer)
Renal failure (kidney dysfunction)
Chest pain
Confusional state
Depression
Alopecia (absence of hair from areas of the body)
Antisocial behaviour
Anxiety

60+:

Back pain
Nausea (feeling of having an urge to vomit)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Decreased appetite
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Epistaxis (bleed from the nose)
Failure to thrive (inadequate weight gain and physical growth in children)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Depression: 7 people, 16.28%
Diabetes: 7 people, 16.28%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 16.28%
High Blood Pressure: 7 people, 16.28%
Stress And Anxiety: 6 people, 13.95%
Asthma: 6 people, 13.95%
Pain: 6 people, 13.95%
High Blood Cholesterol: 6 people, 13.95%
Inflammation: 5 people, 11.63%
Neuralgia (pain in one or more nerves): 5 people, 11.63%

* Approximation only. Some reports may have incomplete information.

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