Divalproex and Calcium citrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Calcium citrate (calcium). Common drug interactions include arthritis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Calcium citrate. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Calcium citrate?

Calcium citrate has active ingredients of calcium. It is often used in osteopenia. eHealthMe is studying from 12,607 Calcium citrate users. Check the latest studies of Calcium citrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

38 people who take Divalproex and Calcium citrate together, and have interactions are studied.

Divalproex and Calcium citrate drug interactions.

What are the common drug interactions of Divalproex and Calcium Citrate, by gender? *:

female:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Haematoma (collection of blood outside the blood vessels)
Infusion site bruising
Infusion site discomfort
Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Sinusitis (inflammation of sinus)
Urinary tract infection
Eye infection
Hip arthroplasty

male:

Abdominal pain
Blood iron decreased
Abdominal discomfort
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Asthenia (weakness)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood creatine phosphokinase increased
Burning sensation
Cardiac disorder

What are the common drug interactions of Divalproex and Calcium Citrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood calcium decreased
Disease recurrence

30-39:

Anxiety
Depression
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Stress
Suicidal ideation
Weight decreased

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Dehydration (dryness resulting from the removal of water)
Gastritis (inflammation of stomach)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Pancreatic cyst
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Eye infection
Urinary tract infection
Infusion site irritation
Allergy to plants
Abdominal discomfort
Cataract (clouding of the lens inside the eye)
Dehydration (dryness resulting from the removal of water)
Hypertension (high blood pressure)
Pain

What are the existing conditions these people have? *

Insomnia (sleeplessness): 9 people, 23.68%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 18.42%
Immunodeficiency Common Variable: 7 people, 18.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 10.53%
Stress And Anxiety: 2 people, 5.26%
Sinusitis (inflammation of sinus): 2 people, 5.26%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 5.26%
Pain: 2 people, 5.26%
Infusion Site Discomfort: 2 people, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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