Divalproex and Chantix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Chantix (varenicline tartrate). Common drug interactions include malaise among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Chantix. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

On Jul, 06, 2026

49 people who take Divalproex and Chantix together, and have interactions are studied.

Divalproex and Chantix drug interactions.

What are the common drug interactions of Divalproex and Chantix, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Nervousness
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Suicide attempt
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection
Acute lung injury
Anger

male:

Chronic kidney disease
Anxiety
Bone density decreased
Drug ineffective
Headache (pain in head)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Abnormal behaviour
Acute myocardial infarction (acute heart attack)
Alcohol abuse

What are the common drug interactions of Divalproex and Chantix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

Aggression
Blood glucose decreased
Diabetes mellitus inadequate control
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Irritability
Mania (a state of abnormally elevated or irritable mood)
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Screaming (a long loud piercing cry)

40-49:

Acute lung injury
Aggression
Chronic kidney disease
Injury
Mood swings (an extreme or rapid change in mood)
Pneumonia
Suicidal ideation
Renal failure (kidney dysfunction)
Depression
Abnormal behaviour

50-59:

Agitation (state of anxiety or nervous excitement)
Anxiety
Chronic kidney disease
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Stress
Vomiting
Irritability
Anger
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

60+:

Abdominal discomfort
Nausea (feeling of having an urge to vomit)
Mood altered (changes in mood)
Vomiting
Dependence
Dyspnoea (difficult or laboured respiration)
Abnormal dreams
Joint swelling
Muscle swelling
Abdominal pain upper

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 20.41%
Stress And Anxiety: 10 people, 20.41%
Depression: 8 people, 16.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 16.33%
Asthma: 6 people, 12.24%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 12.24%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 10.20%
Insomnia (sleeplessness): 5 people, 10.20%
Hiv Infection: 5 people, 10.20%
Diabetes: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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