Divalproex and Eszopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Eszopiclone (eszopiclone). Common drug interactions include stress urinary incontinence among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Eszopiclone. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Eszopiclone?

Eszopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 4,258 Eszopiclone users. Check the latest studies of Eszopiclone.

On Jul, 13, 2026

34 people who take Divalproex and Eszopiclone together, and have interactions are studied.

Divalproex and Eszopiclone drug interactions.

What are the common drug interactions of Divalproex and Eszopiclone, by gender? *:

female:

Stress urinary incontinence (leak urine with things like coughing, sneezing or exercise)
Urinary hesitation (difficulty in beginning the flow of urine)
Vitamin d deficiency
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)
Yellow skin
Depression
Dyspepsia (indigestion)
Nausea (feeling of having an urge to vomit)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Hip arthroplasty
Osteopenia (a condition where bone mineral density is lower than normal)
Rotator cuff repair
Spinal cord injury
Upper limb fracture
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arteriovenous malformation
Fracture

What are the common drug interactions of Divalproex and Eszopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Eye irritation
Therapeutic response decreased (less preventive response)
Drug hypersensitivity
Fear
Hallucination, visual (seeing things that aren't there)

40-49:

Anxiety
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Hip arthroplasty
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

50-59:

Scab (a hard coating on the skin formed during the wound healing)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Abnormal behaviour
Confusional state
Death
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose

60+:

Death
Confusional state
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Hiv Infection: 4 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.88%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 5.88%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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