Divalproex and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include osteopenia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Hydrocodone. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 14, 2026

41 people who take Divalproex and Hydrocodone together, and have interactions are studied.

Divalproex and Hydrocodone drug interactions.

What are the common drug interactions of Divalproex and Hydrocodone, by gender? *:

female:

Osteopenia (a condition where bone mineral density is lower than normal)
Panic attack
Radius fracture
Renal injury (kidney injury)
Skeletal injury (bone and supporting muscle injury)
Sneezing
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Swelling face
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tardive dyskinesia (a disorder that involves involuntary movements)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aggression
Balance disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Depression
Dysphagia (a condition in which swallowing is difficult or painful)
Dysstasia (difficulty in standing)
Gait disturbance
General physical health deterioration (weak health status)

What are the common drug interactions of Divalproex and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Chronic kidney disease
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Cough
Depression
Dry mouth
Emotional distress
Fatigue (feeling of tiredness)
Herpes zoster

50-59:

Renal failure (kidney dysfunction)
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Fall
Hypotension (abnormally low blood pressure)
Spinal fracture (fracture in one of vertebrae)
Anaemia (lack of blood)
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Balance disorder
Cardiovascular disorder (heart diseases)
Cataract (clouding of the lens inside the eye)
Chills (felling of cold)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 26.83%
High Blood Pressure: 9 people, 21.95%
Pain: 9 people, 21.95%
Stress And Anxiety: 7 people, 17.07%
High Blood Cholesterol: 7 people, 17.07%
Hiv Infection: 7 people, 17.07%
Infection: 5 people, 12.20%
Hypersensitivity: 5 people, 12.20%
Cardiac Disorder: 5 people, 12.20%
Parkinson's Disease: 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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