Divalproex and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Oxycontin (oxycodone hydrochloride). Common drug interactions include peripheral swelling among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Oxycontin. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

On Jul, 13, 2026

63 people who take Divalproex and Oxycontin together, and have interactions are studied.

Divalproex and Oxycontin drug interactions.

What are the common drug interactions of Divalproex and Oxycontin, by gender? *:

female:

Peripheral swelling
Renal disorder (kidney disease)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Anxiety
Fall
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Sedation

male:

Drug dependence
Asthenia (weakness)
Chest pain
Cough
Disability
Disturbance in attention
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Dysstasia (difficulty in standing)
Dysuria (painful or difficult urination)
Erectile dysfunction

What are the common drug interactions of Divalproex and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Death
Substance abuse
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)
Delusion (a false belief or opinion)
Drug intolerance (drug sensitivity)
Heart rate increased
Hyperglycaemia (high blood sugar)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Insomnia (sleeplessness)

30-39:

Asthenia (weakness)
Hypoaesthesia (reduced sense of touch or sensation)
Migraine (headache)
Neck pain
Pain in extremity
Prostatitis (inflammation of the prostate gland)
Renal disorder (kidney disease)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Accidental death
Anxiety

40-49:

Fatigue (feeling of tiredness)
Vomiting
Asthenia (weakness)
Back disorder
Cardiac disorder
Chest discomfort
Chest pain
Cough
Disability
Disturbance in attention

50-59:

Lung disorder (lung disease)
Mobility decreased (ability to move is reduced)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Muscular weakness (muscle weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrogenic anaemia (anaemia due to kidney disease)
Nuclear magnetic resonance imaging brain
Obesity (having too much body fat)
Oropharyngeal pain

60+:

Pneumonia
Bradycardia (abnormally slow heart action)
Hallucination (an experience involving the perception of something not present)
Heart rate irregular
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder
Renal failure (kidney dysfunction)
Diarrhoea

What are the existing conditions these people have? *

Stress And Anxiety: 13 people, 20.63%
Depression: 12 people, 19.05%
High Blood Pressure: 11 people, 17.46%
Indigestion: 9 people, 14.29%
High Blood Cholesterol: 8 people, 12.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 12.70%
Enlarged Prostate: 6 people, 9.52%
Cardiac Failure Congestive: 6 people, 9.52%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 6 people, 9.52%
Back Pain: 5 people, 7.94%

* Approximation only. Some reports may have incomplete information.

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