Divalproex and Quinapril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Quinapril (quinapril hydrochloride). Common drug interactions include arthralgia among females and extrapyramidal disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Quinapril. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Quinapril?

Quinapril has active ingredients of quinapril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 12,927 Quinapril users. Check the latest studies of Quinapril.

On Jul, 25, 2026

60 people who take Divalproex and Quinapril together, and have interactions are studied.

Divalproex and Quinapril drug interactions.

What are the common drug interactions of Divalproex and Quinapril, by gender? *:

female:

Arthralgia (joint pain)
Death
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fall
Intestinal obstruction
Pain in extremity
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Confusional state
Hallucination, visual (seeing things that aren't there)
Intention tremor (brain tremor)
Skin ulcer
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nystagmus (a condition of involuntary eye movement)
Aphasia (damage to the parts of the brain that control language)

What are the common drug interactions of Divalproex and Quinapril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Overdose
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Suicide attempt
Electrocardiogram qt prolonged
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Substance abuse

40-49:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Eye disorder
Ulcerative keratitis (ulcerative inflammation of the cornea)
Skin ulcer
Arthropathy
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Weight decreased
Anxiety
Atelectasis (partial or complete collapse of the lung)
Blood glucose fluctuation

50-59:

Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)
Ataxia (loss of full control of bodily movements)
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Confusional state
Delirium (wild excitement)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hallucination, visual (seeing things that aren't there)
Intention tremor (brain tremor)
Sedation
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

60+:

Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)
Nystagmus (a condition of involuntary eye movement)
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Thyroid cancer metastatic (thyroid cancer spreads to other part)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Delirium (wild excitement)

What are the existing conditions these people have? *

Depression: 31 people, 51.67%
Diabetes Insipidus - Nephrogenic (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 12 people, 20.00%
Dyslipidaemia (abnormal amount of lipids): 11 people, 18.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 11.67%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 7 people, 11.67%
Cogwheel Rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched): 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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