Doxil and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxil (doxorubicin hydrochloride) and Aldactone (spironolactone). Common drug interactions include diarrhoea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Doxil and Aldactone. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Doxil?

Doxil has active ingredients of doxorubicin hydrochloride. It is often used in ovarian cancer. eHealthMe is studying from 10,479 Doxil users. Check the latest studies of Doxil.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 29, 2026

51 people who take Doxil and Aldactone together, and have interactions are studied.

What are the common drug interactions of Doxil and Aldactone, by gender? *:

female:

Diarrhoea
Dilated cardiomyopathy
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Fall
Food intolerance (inability to have food)
Glomerular filtration rate decreased
Hepatomegaly (abnormal enlargement of the liver)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypophagia (reduced food intake)

male:

Dyspnoea (difficult or laboured respiration)
Haematocrit decreased
Bacterial infection
Blood urine present
Cough
Excoriation (to tear or wear off the skin of)
Fracture
General nutrition disorder
Glossitis (infection of tongue with soreness)
Hepatic failure (liver failure)

What are the common drug interactions of Doxil and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bacterial infection
General nutrition disorder
Haematocrit decreased
Neutrophil percentage increased
Platelet count decreased
Pleural effusion (water on the lungs)
Pneumonia

30-39:

n/a

40-49:

Refractory anaemia with an excess of blasts (one or more cell types are low in the blood and look abnormal in the bone marrow)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Enterococcal infection
Stenotrophomonas infection
Sinusitis (inflammation of sinus)
Gingival ulceration (ulcer on gums)
Bacterial sepsis
Ascites (accumulation of fluid in the abdominal cavity)
Asthma
Fatigue (feeling of tiredness)

50-59:

Arthralgia (joint pain)
Glomerular filtration rate decreased
Malignant neoplasm progression (cancer tumour came back)
Myalgia (muscle pain)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)

60+:

Cancer pain
Malignant ascites (a condition in which a person with cancer has an accumulation of fluid in the abdomen)
Anaemia (lack of blood)
Bacteraemia (presence of bacteria in the blood)
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Compression fracture (fracture due to pressure caused by injury)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Depression
Haematocrit decreased

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 13 people, 25.49%
Diffuse Large B-Cell Lymphoma Stage Iv (cancer of b cells, a type of white blood cell-stage iv): 13 people, 25.49%
Refractory Anaemia With An Excess Of Blasts (one or more cell types are low in the blood and look abnormal in the bone marrow): 12 people, 23.53%
High Blood Pressure: 8 people, 15.69%
Ovarian Cancer Recurrent (reoccurrence of ovary cancer): 6 people, 11.76%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 11.76%
Ovarian Cancer (cancer of ovary): 6 people, 11.76%
Multiple Myeloma (cancer of the plasma cells): 5 people, 9.80%
Malignant Ascites (a condition in which a person with cancer has an accumulation of fluid in the abdomen): 5 people, 9.80%
Leukopenia (less number of white blood cells in blood): 5 people, 9.80%

* Approximation only. Some reports may have incomplete information.

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