Doxil and Ifex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxil (doxorubicin hydrochloride) and Ifex (ifosfamide). Common drug interactions include myelodysplastic syndrome among females and cardiotoxicity among males.

The phase IV clinical study analyzes what interactions people have when they take Doxil and Ifex. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Doxil?

Doxil has active ingredients of doxorubicin hydrochloride. It is often used in ovarian cancer. eHealthMe is studying from 10,479 Doxil users. Check the latest studies of Doxil.

What is Ifex?

Ifex has active ingredients of ifosfamide. eHealthMe is studying from 829 Ifex users. Check the latest studies of Ifex.

On Jul, 19, 2026

49 people who take Doxil and Ifex together, and have interactions are studied.

What are the common drug interactions of Doxil and Ifex, by gender? *:

female:

Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Cardiotoxicity (damage to the heart muscle)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Febrile neutropenia (fever with reduced white blood cells)
Fungaemia (fungi circulate in the blood)
Fungal infection
Neutropenia (an abnormally low number of neutrophils)
Second primary malignancy (after getting cure a cancer, a new cancer development)
Thrombocytopenia (decrease of platelets in blood)
Back pain

male:

Cardiotoxicity (damage to the heart muscle)
Neoplasm recurrence (reoccurrence of tumour)
Metastases to lymph nodes (cancer spreads to lymph node)
Mucosal inflammation (infection of mucous membrane)
Neutropenia (an abnormally low number of neutrophils)
Respiratory failure (inadequate gas exchange by the respiratory system)
Small intestinal obstruction (blockage in small intestine)
Angiomyolipoma (most common benign tumour of the kidney)
Death
Drug intolerance (drug sensitivity)

What are the common drug interactions of Doxil and Ifex, by age (0-1 to 60+)? *:

0-1:

Drug ineffective

2-9:

Cardiotoxicity (damage to the heart muscle)
Selective mutism (normally capable of speech is unable to speak in given situations)
Ejection fraction decreased (systolic heart failure)
Febrile neutropenia (fever with reduced white blood cells)
Herpes simplex (herpes simplex is a common viral infection)
Meningitis tuberculous (a bacterial infection of the membranes covering the brain and spinal cord (meninges))
Mucosal inflammation (infection of mucous membrane)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Respiratory disorder (respiratory disease)
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

Cardiotoxicity (damage to the heart muscle)
Ejection fraction decreased (systolic heart failure)
Epistaxis (bleed from the nose)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Osteoporosis (bones weak and more likely to break)
Paranasal sinus mucosal hypertrophy (paranasal sinus mucosal enlargement from the increase in size of its cells)
Premature menopause

20-29:

Neoplasm recurrence (reoccurrence of tumour)
Neoplasm progression (growth of tumour)
Bacteraemia (presence of bacteria in the blood)
Febrile neutropenia (fever with reduced white blood cells)
Fungaemia (fungi circulate in the blood)
Fungal infection
Malignant neoplasm progression (cancer tumour came back)
Metastases to liver (cancer spreads to liver)
Metastases to lymph nodes (cancer spreads to lymph node)
Neutropenia (an abnormally low number of neutrophils)

30-39:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Drug intolerance (drug sensitivity)
Mucosal inflammation (infection of mucous membrane)
Neutropenia (an abnormally low number of neutrophils)

40-49:

Second primary malignancy (after getting cure a cancer, a new cancer development)
Febrile neutropenia (fever with reduced white blood cells)
Back pain
Leukoerythroblastosis (immature white blood cells due to bone marrow lesion)
Myeloid leukaemia (a type of cancer in which the bone marrow makes abnormal myeloblasts)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Syncope (loss of consciousness with an inability to maintain postural tone)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

50-59:

Pericarditis (inflammation of the pericardium)

60+:

Angiomyolipoma (most common benign tumour of the kidney)
Infection
Malignant neoplasm progression (cancer tumour came back)
Neutropenia (an abnormally low number of neutrophils)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Scedosporium infection (a filamentous fungus which occasionally causes infections in humans)

What are the existing conditions these people have? *

Burkitt's Lymphoma (cancer of the lymphatic system): 7 people, 14.29%
Burkitt Lymphoma (cancer of the lymphatic system): 6 people, 12.24%
Osteosarcoma (a cancerous (malignant) bone tumour): 5 people, 10.20%
Undifferentiated Sarcoma (undifferentiated cancer): 3 people, 6.12%
Neoplasm Recurrence (reoccurrence of tumour): 3 people, 6.12%
Metastases To Pancreas (cancer spreads to pancreas): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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