Doxycycline and Chestnut drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Chestnut (horse chestnut). Common drug interactions include sinusitis among females and epistaxis among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Chestnut. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Chestnut?

Chestnut has active ingredients of horse chestnut. eHealthMe is studying from 538 Chestnut users. Check the latest studies of Chestnut.

On Aug, 12, 2026

20 people who take Doxycycline and Chestnut together, and have interactions are studied.

Doxycycline and Chestnut drug interactions.

What are the common drug interactions of Doxycycline and Chestnut, by gender? *:

female:

Sinusitis (inflammation of sinus)
Colitis (inflammation of colon)
Depression
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation
Cough
Ear pain
Fatigue (feeling of tiredness)

male:

Epistaxis (bleed from the nose)
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Blood glucose decreased
Blood pressure increased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depression
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Doxycycline and Chestnut, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Colitis (inflammation of colon)
Depression
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Inflammation
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation

30-39:

Depression
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

40-49:

n/a

50-59:

Blood glucose decreased
Blood pressure increased
Chronic kidney disease
Gout (uric acid crystals building up in the body)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

60+:

Epistaxis (bleed from the nose)
Urinary tract infection

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 50.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 20.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 10.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 10.00%
Gout (uric acid crystals building up in the body): 1 person, 5.00%
Blood Potassium Decreased: 1 person, 5.00%
Cardiac Disorder: 1 person, 5.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.00%
Cyst (a closed sac): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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