Doxycycline and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Keytruda (pembrolizumab). Common drug interactions include neuropathy peripheral among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Keytruda. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

On Jul, 17, 2026

45 people who take Doxycycline and Keytruda together, and have interactions are studied.

Doxycycline and Keytruda drug interactions.

What are the common drug interactions of Doxycycline and Keytruda, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Urinary tract infection
Vomiting
Asthenia (weakness)
Autoimmune myocarditis (inflammation of the heart muscle by immune system disorder)
Death
Dehydration (dryness resulting from the removal of water)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)

male:

Diarrhoea
Fatigue (feeling of tiredness)
Bone pain
Chills (felling of cold)
Constipation
Dry skin
Hypotension (abnormally low blood pressure)
Inflammation
Infusion site bruising
Infusion site haemorrhage (bleeding from infusion site)

What are the common drug interactions of Doxycycline and Keytruda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Death

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Autoimmune arthritis (joint inflammation)
Blood urine present
Decreased appetite
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer)
Malignant neoplasm progression (cancer tumour came back)
Nausea (feeling of having an urge to vomit)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Stomatitis (inflammation of mucous membrane of mouth)

50-59:

Urinary tract infection
Vomiting
Blood iron decreased
Cancer pain
Constipation
Dizziness
Dry skin
Fatigue (feeling of tiredness)
Haemoglobin decreased
Lymphoedema (localized fluid retention and tissue swelling)

60+:

Constipation
Diarrhoea
Balance disorder
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone pain
Chills (felling of cold)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Inflammation

What are the existing conditions these people have? *

Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 7 people, 15.56%
Malignant Melanoma (skin cancer rises from melancytes): 7 people, 15.56%
Endometrial Cancer: 5 people, 11.11%
Pain: 4 people, 8.89%
Stress And Anxiety: 3 people, 6.67%
Sleep Disorder: 3 people, 6.67%
Osteoporosis (bones weak and more likely to break): 3 people, 6.67%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 6.67%
Joint Pain: 3 people, 6.67%
Affective Disorder (mental disorder): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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