Mirapex and Prempro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mirapex (pramipexole dihydrochloride) and Prempro (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include chondromalacia among females and alopecia among males.

The phase IV clinical study analyzes what interactions people have when they take Mirapex and Prempro. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Mirapex?

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 20,622 Mirapex users. Check the latest studies of Mirapex.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

On Jul, 17, 2026

82 people who take Mirapex and Prempro together, and have interactions are studied.

What are the common drug interactions of Mirapex and Prempro, by gender? *:

female:

Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Colonic polyp (extra part of colon tissue grow in intestine)
Dermoid cyst (an abnormal growth (teratoma) containing epidermis, hair follicles, and sebaceous glands)
Dry skin
Essential hypertension (primary hypertension)
Fistula discharge (discharge from abnormal passage of structure/organ)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart valve replacement

male:

Alopecia (absence of hair from areas of the body)
Blood testosterone increased
Hypertrophy breast (increase in the volume of breast due to the enlargement of its component cells)
Respiratory rate increased (excess breathing rate/min)
Temporal lobe epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe)
Breast discharge
Breast tenderness
Crying
Cushing's syndrome (obesity, a rounded face, increased fat)
Emotional disorder

What are the common drug interactions of Mirapex and Prempro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)
Blood testosterone increased
Breast discharge
Breast tenderness
Crying
Cushing's syndrome (obesity, a rounded face, increased fat)
Emotional disorder
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hypertrophy breast (increase in the volume of breast due to the enlargement of its component cells)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)

40-49:

Blood pressure increased
Chronic kidney disease
Dizziness (excl vertigo)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injection site inflammation

50-59:

Myalgia (muscle pain)
Exostosis (formation of new bone on the surface of a bone)
Oral infection
Oral torus (a lesion made of compact bone and occurs along the palate or the mandible inside the mouth)
Osteonecrosis (death of bone)
Osteonecrosis of jaw (death of bone of jaw)
Soft tissue disorder (disease of soft tissue)
Ulcer
Femur fracture
Fracture nonunion (permanent failure of healing following a broken bone)

60+:

Drug ineffective
Hot flush (sudden feelings of heat)
Tremor (trembling or shaking movements in one or more parts of your body)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Balance disorder
Blindness
Body height decreased
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 18.29%
Osteoporosis (bones weak and more likely to break): 15 people, 18.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 14.63%
Parkinson's Disease: 11 people, 13.41%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 9.76%
Pain: 7 people, 8.54%
Migraine (headache): 7 people, 8.54%
Hypersensitivity: 6 people, 7.32%
Depression: 6 people, 7.32%
Back Pain: 6 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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