Drospirenone and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Drospirenone (drospirenone) and Spironolactone (spironolactone). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Drospirenone and Spironolactone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Drospirenone?

Drospirenone has active ingredients of drospirenone. eHealthMe is studying from 603 Drospirenone users. Check the latest studies of Drospirenone.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

20 people who take Drospirenone and Spironolactone together, and have interactions are studied.

Drospirenone and Spironolactone drug interactions.

What are the common drug interactions of Drospirenone and Spironolactone, by gender? *:

female:

Drug ineffective
Pain
Pruritus (severe itching of the skin)
Psoriasis (immune-mediated disease that affects the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Abdominal pain upper
Drug hypersensitivity
Feeling hot
Fistula discharge (discharge from abnormal passage of structure/organ)
Hidradenitis (chronic disease of a type of sweat gland)

male:

n/a

What are the common drug interactions of Drospirenone and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Vomiting

20-29:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Dry skin
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Injection site bruising
Pruritus (severe itching of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Abscess (pus)
Cellulitis (infection under the skin)
Depressive symptom
Drug ineffective

30-39:

Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Vision blurred
Visual impairment

40-49:

n/a

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

n/a

What are the existing conditions these people have? *

Nodule (a growth of abnormal tissue): 7 people, 35.00%
Hidradenitis (chronic disease of a type of sweat gland): 7 people, 35.00%
Abscess (pus): 5 people, 25.00%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 15.00%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 15.00%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 5.00%
Excessive Or Unwanted Hair In Women: 1 person, 5.00%
Constipation: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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