Dulcolax and Suboxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dulcolax (bisacodyl) and Suboxone (buprenorphine hydrochloride; naloxone hydrochloride). Common drug interactions include limb injury among females and application site burn among males.

The phase IV clinical study analyzes what interactions people have when they take Dulcolax and Suboxone. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Dulcolax?

Dulcolax has active ingredients of bisacodyl. It is often used in constipation. eHealthMe is studying from 12,897 Dulcolax users. Check the latest studies of Dulcolax.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,250 Suboxone users. Check the latest studies of Suboxone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

18 people who take Dulcolax and Suboxone together, and have interactions are studied.

Dulcolax and Suboxone drug interactions.

What are the common drug interactions of Dulcolax and Suboxone, by gender? *:

female:

Limb injury
Psychotic disorder
Cervix cancer metastatic (cancer of cervix spreading to other organ)
Cervix carcinoma stage ii (cancer has spread beyond the cervix but not to the pelvic wall)
Fall
Granulocytopenia (lack of granulocyte)
Hip fracture
Malaise (a feeling of general discomfort or uneasiness)
Metastatic neoplasm (spreadable cancer tumour)
Ovarian cancer (cancer of ovary)

male:

Application site burn
Application site pruritus (application site severe itching of the skin)
Weight increased
Death
Device failure
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fall
Hyperhidrosis (abnormally increased sweating)
Lung carcinoma cell type unspecified recurrent (lung cancer reoccurrence)

What are the common drug interactions of Dulcolax and Suboxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Limb injury
Psychotic disorder
Hyperhidrosis (abnormally increased sweating)
Lung carcinoma cell type unspecified recurrent (lung cancer reoccurrence)
Malaise (a feeling of general discomfort or uneasiness)
Metastatic neoplasm (spreadable cancer tumour)
Ovarian cancer (cancer of ovary)
Rash
Red blood cell count decreased
Terminal state (the transitional states between life and biological death)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 16.67%
Pain: 2 people, 11.11%
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1 person, 5.56%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 5.56%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 5.56%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 1 person, 5.56%
Depression: 1 person, 5.56%
Hypersensitivity: 1 person, 5.56%
Insomnia (sleeplessness): 1 person, 5.56%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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