Duphalac and Haldol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duphalac (lactulose) and Haldol (haloperidol). Common drug interactions include cyanosis among females and loss of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Duphalac and Haldol. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Haldol?

Haldol has active ingredients of haloperidol. It is often used in schizophrenia. eHealthMe is studying from 23,102 Haldol users. Check the latest studies of Haldol.



On Jul, 20, 2026

98 people who take Duphalac and Haldol together, and have interactions are studied.

Duphalac and Haldol drug interactions.

What are the common drug interactions of Duphalac and Haldol, by gender? *:

female:

  1. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  2. Cytomegalovirus infection
  3. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  4. Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
  5. Hyporeflexia (a condition of below normal or absent reflexes)
  6. Hypotonia (low muscle tone)
  7. Mania (a state of abnormally elevated or irritable mood)
  8. Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
  9. Oxygen saturation decreased
  10. Pemphigoid (tense blisters on the skin)

male:

  1. Loss of consciousness
  2. Mydriasis (a dilation of the pupil)
  3. Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
  4. Pancreatitis acute (sudden inflammation of pancreas)
  5. Pruritus (severe itching of the skin)
  6. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  7. Hypotension (abnormally low blood pressure)
  8. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  9. Blood bilirubin increased
  10. Catatonia (unresponsive to external stimuli)

What are the common drug interactions of Duphalac and Haldol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Hyperprolactinaemia (abnormally high levels of prolactin in the blood)

30-39:

  1. Drug eruption (adverse drug reaction of the skin)
  2. Eosinophilia (eosinophil count in the peripheral blood exceeds)
  3. Pancreatitis acute (sudden inflammation of pancreas)
  4. Oedema peripheral (superficial swelling)
  5. Pneumococcal sepsis (pneumococcal sepsis is a serious medical condition where bacteria, specifically streptococcus pneumoniae)
  6. Rash erythematous (redness of the skin)
  7. Skin exfoliation (removal of the oldest dead skin cells)

40-49:

  1. Coma (state of unconsciousness lasting more than six hours)
  2. Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
  3. Pruritus (severe itching of the skin)
  4. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  5. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  6. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  7. Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
  8. Hyporeflexia (a condition of below normal or absent reflexes)
  9. Hypotonia (low muscle tone)
  10. Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)

50-59:

  1. Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
  2. Ileus (a painful obstruction of the ileum or other part of the intestine)
  3. Oesophageal candidiasis (fungal infection of oesophagus)
  4. Oral candidiasis (fungal infection of mouth)
  5. Pericarditis (inflammation of the pericardium)
  6. Pleural effusion (water on the lungs)
  7. Respiratory depression (respiration has a rate below 12 breaths)
  8. Somnolence (a state of near-sleep, a strong desire for sleep)
  9. Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
  10. Subileus

60+:

  1. Intestinal obstruction
  2. Pancreatitis acute (sudden inflammation of pancreas)
  3. Abdominal pain
  4. Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
  5. Acute respiratory distress syndrome
  6. Alveolitis (inflammation in the socket of a tooth)
  7. Blood bilirubin increased
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  9. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  10. Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

  1. Stress And Anxiety: 15 people, 15.31%
  2. Insomnia (sleeplessness): 14 people, 14.29%
  3. Psychotic Disorder: 8 people, 8.16%
  4. Depression: 8 people, 8.16%
  5. Bipolar Disorder (mood disorder): 8 people, 8.16%
  6. High Blood Pressure: 7 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Duphalac and Haldol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Duphalac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Haldol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Duphalac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Haldol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on lactulose and haloperidol (the active ingredients of Duphalac and Haldol, respectively), and Duphalac and Haldol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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