Dynacirc and Prograf drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Dynacirc (isradipine) and Prograf (tacrolimus). Common drug interactions include pain among females and nephrogenic systemic fibrosis among males.
The phase IV clinical study analyzes what interactions people have when they take Dynacirc and Prograf. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.
What is Dynacirc?
Dynacirc has active ingredients of isradipine. eHealthMe is studying from 975 Dynacirc users. Check the latest studies of Dynacirc.
What is Prograf?
Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.
15 people who take Dynacirc and Prograf together, and have interactions are studied.

What are the common drug interactions of Dynacirc and Prograf, by gender? *:
female:
- Pain
- Anxiety
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Dizziness
- Dysgeusia (disorder of the sense of taste)
- Emotional distress
- Feeling drunk
- General physical health deterioration (weak health status)
- Hypoacusis (loss of hearing)
- Injury
male:
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Mobility decreased (ability to move is reduced)
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
- Asthma
- Blood creatinine increased
- Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
- Depression
- Discomfort
- Drug ineffective
- Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
What are the common drug interactions of Dynacirc and Prograf, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Pancreatitis (inflammation of pancreas)
10-19:
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
- Blood creatinine increased
- Mouth ulceration (mouth ulcers)
- Scoliosis (a medical condition in which a person's spine is curved from side to side)
- Stomatitis (inflammation of mucous membrane of mouth)
- Therapeutic response decreased (less preventive response)
20-29:
n/a
30-39:
- Asthma
- Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
- Depression
- Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
- Fatigue (feeling of tiredness)
- Joint contracture (a permanent shortening of a muscle or joint)
- Joint stiffness
- Memory impairment
- Mobility decreased (ability to move is reduced)
- Muscle tightness
40-49:
n/a
50-59:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Dizziness
- Feeling drunk
- Head injury
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Pain
- Post concussion syndrome
- Syncope (loss of consciousness with an inability to maintain postural tone)
60+:
- Anxiety
- Dysgeusia (disorder of the sense of taste)
- Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
- Skin tightness
- Therapeutic response decreased (less preventive response)
- Emotional distress
- General physical health deterioration (weak health status)
- Hypoacusis (loss of hearing)
- Injury
- Mobility decreased (ability to move is reduced)
What are the existing conditions these people have? *
- Pain: 1 person, 6.67%
- Neoplasm Malignant (cancer tumour): 1 person, 6.67%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%
- Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
- Infection: 1 person, 6.67%
- High Blood Pressure: 1 person, 6.67%
- Erection Problems: 1 person, 6.67%
- Bone Marrow Transplant Rejection: 1 person, 6.67%
- Body Height Below Normal: 1 person, 6.67%
- Anal Fungal Infection: 1 person, 6.67%
* Approximation only. Some reports may have incomplete information.
Do you take Dynacirc and Prograf?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Dynacirc and Prograf:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Dynacirc:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Prograf:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Dynacirc and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Prograf and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on isradipine and tacrolimus (the active ingredients of Dynacirc and Prograf, respectively), and Dynacirc and Prograf (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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