Fluoxetine and Venous insufficiency - a phase IV clinical study of FDA data

Summary:

Venous insufficiency is reported as a side effect among people who take Fluoxetine (fluoxetine hydrochloride), especially for people who are female, 60+ old, also take Folic Acid, and have Osteopenia.

The phase IV clinical study analyzes which people have Venous insufficiency when taking Fluoxetine. It is created by eHealthMe based on reports of 94,370 people who have side effects when taking Fluoxetine from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,819 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Venous insufficiency?

Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins) is found to be associated with 392 drugs and 557 conditions by eHealthMe. Check the latest studies of Venous insufficiency.

On Apr, 18, 2026

94,370 people reported to have side effects when taking Fluoxetine.
Among them, 25 people (0.03%) have Venous insufficiency.

Could Fluoxetine cause Venous insufficiency?

Among these 25 people:

What is the gender of people who have Venous insufficiency when taking Fluoxetine? *

female: 60 %
male: 40 %

What is the age of people who have Venous insufficiency when taking Fluoxetine? *

What are other drugs people take besides Fluoxetine? *

What are other side effects people have besides Venous insufficiency? *

Fall: 16 people, 64.00%
High Blood Pressure: 14 people, 56.00%
Fatigue (feeling of tiredness): 13 people, 52.00%
Pain: 12 people, 48.00%
Pain In Extremity: 12 people, 48.00%
Oedema Peripheral (superficial swelling): 11 people, 44.00%
Gastritis (inflammation of stomach): 11 people, 44.00%
Anaemia (lack of blood): 9 people, 36.00%
Abdominal Pain: 8 people, 32.00%
Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 32.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 5 people, 20.00%
Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 16.00%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 3 people, 12.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 12.00%
Cervicobrachial Syndrome (pain in neck and arm with changing location): 3 people, 12.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 4.00%
Ill-Defined Disorder: 1 person, 4.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 4.00%
Anaemia (lack of blood): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Fluoxetine and have Venous insufficiency?

- Check whether Venous insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluoxetine:

Fluoxetine (98,819 reports)

Browse all side effects of Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Venous insufficiency:

Venous insufficiency (392 drugs)

Browse all the conditions that are associated with Venous insufficiency:

Venous insufficiency (557 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Fluoxetine) and Fluoxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.