Sertraline and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include fall among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline and Avalide. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

On Jul, 19, 2026

52 people who take Sertraline and Avalide together, and have interactions are studied.

Sertraline and Avalide drug interactions.

What are the common drug interactions of Sertraline and Avalide, by gender? *:

female:

Fall
Fatigue (feeling of tiredness)
Gait disturbance
Hyperglycaemia (high blood sugar)
Pain in extremity
Weight decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Drug ineffective
Heat exhaustion (dizziness and nausea and weakness caused by depletion of body fluids and electrolytes)
Hepatic steatosis (fatty liver disease)

male:

Drug ineffective
Fall
Headache (pain in head)
Pain in extremity
Bone pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Dyspepsia (indigestion)
Pain
Pancreatitis (inflammation of pancreas)

What are the common drug interactions of Sertraline and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Bone pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decreased appetite
Fluid retention (an abnormal accumulation of fluid in the blood)
Food allergy
Generalised oedema (swelling all over the body)
Hypersensitivity
Injection site bruising
Nausea (feeling of having an urge to vomit)
Pain

60+:

Fall
Drug ineffective
Hepatic steatosis (fatty liver disease)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hip fracture
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephrolithiasis (calculi in the kidneys)
Nystagmus (a condition of involuntary eye movement)
Peripheral nerve lesion

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 13.46%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 13.46%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 13.46%
Type 2 Diabetes: 3 people, 5.77%
Gout (uric acid crystals building up in the body): 3 people, 5.77%
Blood Pressure Abnormal: 3 people, 5.77%
Asthma: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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