Effexor xr and Oxycodone hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor xr (venlafaxine hydrochloride) and Oxycodone hydrochloride (oxycodone hydrochloride). Common drug interactions include diarrhoea among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor xr and Oxycodone hydrochloride. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

On Jul, 20, 2026

23 people who take Effexor xr and Oxycodone hydrochloride together, and have interactions are studied.

Effexor xr and Oxycodone hydrochloride drug interactions.

What are the common drug interactions of Effexor Xr and Oxycodone Hydrochloride, by gender? *:

female:

Diarrhoea
Drug ineffective
Muscle spasms (muscle contraction)
Swelling
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac murmur (an heart sound in valve abnormality)
Cough
Generalised oedema (swelling all over the body)
Hypertension (high blood pressure)

male:

Anaemia (lack of blood)
Drug dependence
Thrombocytopenia (decrease of platelets in blood)
Emotional distress
Hypotension (abnormally low blood pressure)
Injury
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Plasma cell myeloma (cancer that begins in plasma cells)

What are the common drug interactions of Effexor Xr and Oxycodone Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Completed suicide (act of taking one's own life)
Loss of consciousness
Angioedema (rapid swelling of the dermis)
Apnoea (suspension of external breathing)
Blood urine present
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Confusional state
Consciousness fluctuating
Contusion (a type of hematoma of tissue in which capillaries)

40-49:

Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac murmur (an heart sound in valve abnormality)
Cough
Diarrhoea
Generalised oedema (swelling all over the body)
Hypertension (high blood pressure)
Leukocytosis (increased white blood cells)
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

50-59:

Pruritus (severe itching of the skin)
Drug ineffective
Fall
Fatigue (feeling of tiredness)
Oesophageal stenosis (narrowing of oesophagus)
Pneumonia
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Anaemia (lack of blood)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Plasma cell myeloma (cancer that begins in plasma cells)
Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 4 people, 17.39%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 13.04%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 3 people, 13.04%
Cough: 3 people, 13.04%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%
Ill-Defined Disorder: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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