Efudex and Xyrem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Efudex (fluorouracil) and Xyrem (sodium oxybate). Common drug interactions include surgery among females and sleep apnoea syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Efudex and Xyrem. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

On Jul, 14, 2026

35 people who take Efudex and Xyrem together, and have interactions are studied.

What are the common drug interactions of Efudex and Xyrem, by gender? *:

female:

Surgery
Drug ineffective
Erythema (redness of the skin)
Eye irritation
Pain
Hepatic steatosis (fatty liver disease)
Panic attack
Blood pressure increased
Headache (pain in head)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)

male:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Blood cholesterol increased
Shoulder operation
Sinusitis (inflammation of sinus)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Anaphylactic reaction (serious allergic reaction)
Death
Skin discolouration (change of skin colour)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Abdominal discomfort

What are the common drug interactions of Efudex and Xyrem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Surgery

50-59:

Abnormal dreams
Irritable bowel syndrome
Stress
Therapeutic response decreased (less preventive response)
Alopecia (absence of hair from areas of the body)
Surgery
Anxiety
Blood pressure increased
Delusion (a false belief or opinion)

60+:

Abdominal discomfort
Diarrhoea
Drug dependence
Nausea (feeling of having an urge to vomit)
Shoulder operation
Death

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 28.57%
Drowsiness: 5 people, 14.29%
Insomnia (sleeplessness): 4 people, 11.43%
Panic Disorder: 3 people, 8.57%
Pain: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

Do you take Efudex and Xyrem?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously