Elavil and Estradiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Estradiol (estradiol). Common drug interactions include angioneurotic oedema among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Estradiol. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

On Jul, 12, 2026

52 people who take Elavil and Estradiol together, and have interactions are studied.

What are the common drug interactions of Elavil and Estradiol, by gender? *:

female:

Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Antinuclear antibody positive
Anxiety
Application site burn
Application site irritation
Application site pruritus (application site severe itching of the skin)
Arrhythmia supraventricular (irregular heartbeat supraventricular origin)
Back disorder
Balance disorder
Blood triglycerides increased

male:

Fall
Pain
Colon cancer
Cough
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Increased upper airway secretion
Joint dislocation (a joint position is changed from normal position)
Oedema peripheral (superficial swelling)
Oropharyngeal pain

What are the common drug interactions of Elavil and Estradiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Weight increased
Blood triglycerides increased

40-49:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Retinopathy (acute damage to the retina of the eye)
Fatigue (feeling of tiredness)
Joint swelling
Weight increased
Abdominal discomfort
Abnormal behaviour
Application site burn
Application site irritation
Application site pruritus (application site severe itching of the skin)

50-59:

Headache (pain in head)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatic steatosis (fatty liver disease)
Hepatic trauma (liver injury)
Ligament sprain (ligament stretched)
Memory impairment
Nausea (feeling of having an urge to vomit)
Oral herpes (viral infection of mouth)
Pruritus (severe itching of the skin)
Smooth muscle antibody positive

60+:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Blood pressure fluctuation
Blood pressure increased
Blood pressure systolic increased
Cough
Cystoid macular oedema (fluid accumulation after cataract surgery)
Dizziness
Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
Feeling cold

What are the existing conditions these people have? *

Pain: 11 people, 21.15%
Stress And Anxiety: 10 people, 19.23%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 13.46%
Cystitis Interstitial (unknown cause characterized by bladder pain): 6 people, 11.54%
High Blood Pressure: 6 people, 11.54%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 9.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.62%
Sleep Disorder: 5 people, 9.62%
Back Pain: 5 people, 9.62%
Migraine (headache): 4 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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