Elavil and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Modafinil (modafinil). Common drug interactions include fall among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Modafinil. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 20, 2026

21 people who take Elavil and Modafinil together, and have interactions are studied.

What are the common drug interactions of Elavil and Modafinil, by gender? *:

female:

Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)
Hallucination (an experience involving the perception of something not present)
Hand dermatitis (hand infection of skin)
Heart rate decreased
Hospitalisation
Hypertension (high blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Infection

male:

Dizziness
Headache (pain in head)
Balance disorder
Blindness
Blood pressure increased
Bone pain
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diplopia (double vision)
Dry mouth

What are the common drug interactions of Elavil and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure increased
Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Heart rate decreased
White blood cell count decreased

40-49:

Injection site atrophy (injection site wasting or decreasing in size of a body organ, tissue, or part)
Injection site nerve damage
Pain in extremity
Radial nerve palsy (paralysis of radial nerve)
Hypoaesthesia (reduced sense of touch or sensation)
Neuropathy peripheral (surface nerve damage)
Arthralgia (joint pain)
Asthenia (weakness)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)

50-59:

Pain
Renal failure (kidney dysfunction)
Abasia (inability to walk)
Asthenia (weakness)
Blood pressure diastolic decreased
Blood pressure systolic increased
Gastric ulcer (stomach ulcer)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Limb injury
Neuralgia (pain in one or more nerves)

60+:

Asthenia (weakness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nerve compression
Sensory loss (senses loss)
Spinal osteoarthritis (joint cartilage loss in spine)
Vessel puncture site haemorrhage (vessel puncture site bleeding)
Infection
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 42.86%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 19.05%
Fatigue (feeling of tiredness): 2 people, 9.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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