Elavil and Vimpat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Vimpat (lacosamide). Common drug interactions include epistaxis among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Vimpat. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Vimpat?

Vimpat has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 20,832 Vimpat users. Check the latest studies of Vimpat.

On Aug, 12, 2026

23 people who take Elavil and Vimpat together, and have interactions are studied.

What are the common drug interactions of Elavil and Vimpat, by gender? *:

female:

Epistaxis (bleed from the nose)
Excessive eye blinking (excessive blinking is dry eyes)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye movement disorder
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glaucoma (increased fluid pressure in the eye with vision loss)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

male:

Fall
Abdominal pain upper
Drug ineffective
Fatigue (feeling of tiredness)
Gait disturbance
Headache (pain in head)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Leukocytosis (increased white blood cells)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Elavil and Vimpat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Abdominal pain upper
Abdominal rigidity
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Back pain
Balance disorder
Blood alkaline phosphatase increased
Blood pressure increased
Confusional state

30-39:

Myalgia (muscle pain)
Pyrexia (fever)
Feeling hot
Photophobia (extreme sensitivity to light)

40-49:

n/a

50-59:

Arteriosclerosis (thickening and hardening of arteries)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Psychotic disorder
Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Vomiting
Aggression
Agitation (state of anxiety or nervous excitement)

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Aphasia (damage to the parts of the brain that control language)
Therapeutic response unexpected
Brain midline shift
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Dysarthria (speech disorder)
Fall
Feeling hot
Hemiparesis (weakness on one side of the body)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 52.17%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 39.13%
Rickets (softening of bones): 7 people, 30.43%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 7 people, 30.43%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 7 people, 30.43%
Insomnia (sleeplessness): 7 people, 30.43%
Hyperkeratosis (thickening of the outer layer of the skin): 7 people, 30.43%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 17.39%
Migraine (headache): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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