Emend and Cosmegen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Emend (aprepitant) and Cosmegen (dactinomycin). Common drug interactions include platelet count decreased among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Emend and Cosmegen. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Cosmegen?

Cosmegen has active ingredients of dactinomycin. eHealthMe is studying from 937 Cosmegen users. Check the latest studies of Cosmegen.

On Jul, 16, 2026

12 people who take Emend and Cosmegen together, and have interactions are studied.

What are the common drug interactions of Emend and Cosmegen, by gender? *:

female:

Platelet count decreased
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Pyrexia (fever)
White blood cell count decreased
Encephalopathy (functioning of the brain is affected by some agent or condition)
Agitation (state of anxiety or nervous excitement)
Altered state of consciousness (altered state of mind)
Facial pain

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage))
Therapeutic response decreased (less preventive response)
Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it)
Areflexia (absence of a reflex)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Device related infection
Diarrhoea

What are the common drug interactions of Emend and Cosmegen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

White blood cell count decreased
Encephalopathy (functioning of the brain is affected by some agent or condition)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Agitation (state of anxiety or nervous excitement)
Altered state of consciousness (altered state of mind)
Areflexia (absence of a reflex)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Device related infection
Diarrhoea

20-29:

n/a

30-39:

Facial pain
Hepatic enzyme increased
Rash generalised (rash on most of body parts)
Swelling face
White blood cell disorder

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 6 people, 50.00%
Wilms Tumor (cancer of the kidneys that typically occurs in children): 1 person, 8.33%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 1 person, 8.33%
Gestational Trophoblastic Disease (disease of foetus surrounding during pregnancy): 1 person, 8.33%
Bone Marrow Failure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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