Enablex and Donepezil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Donepezil (donepezil hydrochloride). Common drug interactions include electrolyte imbalance among females and dementia alzheimer's type among males.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Donepezil. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

On Jul, 13, 2026

32 people who take Enablex and Donepezil together, and have interactions are studied.

Enablex and Donepezil drug interactions.

What are the common drug interactions of Enablex and Donepezil, by gender? *:

female:

Electrolyte imbalance
Gait disturbance
Hydronephrosis (water inside the kidney)
Kidney infection
Leukocytosis (increased white blood cells)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephrolithiasis (calculi in the kidneys)
Pain in extremity
Pyelonephritis (inflammation of kidney caused by bacteria)

male:

Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Insomnia (sleeplessness)
Arrhythmia (irregular heartbeat)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Back pain

What are the common drug interactions of Enablex and Donepezil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

30-39:

n/a

40-49:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Abnormal behaviour
Blood potassium decreased
Blood thyroid stimulating hormone decreased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Confusional state
Dehydration (dryness resulting from the removal of water)
Depressed mood
Dyspepsia (indigestion)
Electrolyte imbalance

50-59:

Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Confusional state
Electrolyte imbalance
Hemiparesis (weakness on one side of the body)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

60+:

Back pain
Dry mouth
Urinary tract infection
Abdominal distension
Abdominal pain upper
Activities of daily living impaired
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Agitation (state of anxiety or nervous excitement)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 28.12%
Depression: 7 people, 21.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 21.88%
Pain: 7 people, 21.88%
High Blood Pressure: 6 people, 18.75%
Stress And Anxiety: 4 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.50%
Memory Loss: 3 people, 9.38%
Back Pain: 3 people, 9.38%
Incontinence (lack of moderation or self-control): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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