Enablex and Keflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Keflex (cephalexin). Common drug interactions include dry mouth among females and fibula fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Keflex. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Keflex?

Keflex has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 15,844 Keflex users. Check the latest studies of Keflex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

28 people who take Enablex and Keflex together, and have interactions are studied.

What are the common drug interactions of Enablex and Keflex, by gender? *:

female:

Dry mouth
Pain in extremity
Vomiting
Abdominal pain
Fall
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspepsia (indigestion)
Facial bones fracture (bone fracture of face)
Foot deformity (functional disability of foot)

male:

Fibula fracture

What are the common drug interactions of Enablex and Keflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
Arthralgia (joint pain)
Back pain
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic kidney disease
Constipation
Dystonia (abnormal muscle tone)
Emotional disorder
Excessive eye blinking (excessive blinking is dry eyes)

50-59:

Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Cystitis interstitial (unknown cause characterized by bladder pain)
Decreased appetite
Deformity (disfigurement)
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Early satiety (feeling full before completing a normal sized meal)
Emotional distress
Epistaxis (bleed from the nose)

60+:

Diarrhoea
Anxiety
Fall
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Intervertebral disc degeneration (spinal disc degeneration)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Pain in extremity

What are the existing conditions these people have? *

Breast Cancer: 8 people, 28.57%
Multiple Myeloma (cancer of the plasma cells): 5 people, 17.86%
Osteoporosis (bones weak and more likely to break): 4 people, 14.29%
Metastases To Bone (cancer spreads to bone): 4 people, 14.29%
Depression: 4 people, 14.29%
Pain: 3 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
Sleep Disorder: 2 people, 7.14%
Nausea (feeling of having an urge to vomit): 2 people, 7.14%
Insomnia (sleeplessness): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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