Enablex and Lorcet-hd drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Lorcet-hd (acetaminophen; hydrocodone bitartrate). Common drug interactions include progressive multifocal leukoencephalopathy among females.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Lorcet-hd. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

On Jul, 13, 2026

12 people who take Enablex and Lorcet-hd together, and have interactions are studied.

Enablex and Lorcet-hd drug interactions.

What are the common drug interactions of Enablex and Lorcet-Hd, by gender? *:

female:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood cholesterol increased
Blood triglycerides increased
Body temperature increased
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

n/a

What are the common drug interactions of Enablex and Lorcet-Hd, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood cholesterol increased
Blood triglycerides increased
Body temperature increased
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 91.67%
Stress And Anxiety: 6 people, 50.00%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 6 people, 50.00%
High Blood Pressure: 6 people, 50.00%
Depression: 6 people, 50.00%
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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