Enablex and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Vytorin (ezetimibe; simvastatin). Common drug interactions include multiple sclerosis relapse among females and cholelithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Vytorin. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

56 people who take Enablex and Vytorin together, and have interactions are studied.

What are the common drug interactions of Enablex and Vytorin, by gender? *:

female:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Cardiac failure
Chest pain
Chills (felling of cold)
Confusional state
Conjunctivitis (pink eye)
Dehydration (dryness resulting from the removal of water)

male:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain

What are the common drug interactions of Enablex and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Coronary arterial stent insertion
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Injection site swelling

30-39:

n/a

40-49:

Abdominal pain upper
Adverse event
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Chest pain
Depression
Diarrhoea
Drug ineffective
Headache (pain in head)
Hyperlipidaemia (presence of excess lipids in the blood)

50-59:

Dehydration (dryness resulting from the removal of water)
Gait disturbance
Hydronephrosis (water inside the kidney)
Kidney infection
Leukocytosis (increased white blood cells)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephrolithiasis (calculi in the kidneys)
Pyelonephritis (inflammation of kidney caused by bacteria)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Drug ineffective

60+:

Pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Pneumonia
Renal failure (kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cardiac failure
Cardiac failure congestive
Conjunctivitis (pink eye)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Type 2 Diabetes: 10 people, 17.86%
High Blood Pressure: 10 people, 17.86%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.71%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.14%
Depression: 4 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.36%
Pain: 3 people, 5.36%
Osteoporosis (bones weak and more likely to break): 3 people, 5.36%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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