Endep and Mobic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Endep (amitriptyline hydrochloride) and Mobic (meloxicam). Common drug interactions include arthralgia among females and drug effect decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Endep and Mobic. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Mobic?

Mobic has active ingredients of meloxicam. It is often used in arthritis. eHealthMe is studying from 26,684 Mobic users. Check the latest studies of Mobic.

On Jul, 16, 2026

55 people who take Endep and Mobic together, and have interactions are studied.

What are the common drug interactions of Endep and Mobic, by gender? *:

female:

Arthralgia (joint pain)
Cough
Dyspnoea (difficult or laboured respiration)
Joint swelling
Pneumonia
Rib fracture
Viral infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fatigue (feeling of tiredness)
Foot deformity (functional disability of foot)

male:

Drug effect decreased

What are the common drug interactions of Endep and Mobic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Wound infection
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram st segment depression
Infection
Influenza
Lethargy (tiredness)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

50-59:

Osteomyelitis (infection of bone)
Anxiety
Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Asthma
Blood pressure increased
Drug effect decreased
Drug ineffective
Joint dislocation (a joint position is changed from normal position)
Lower respiratory tract infection

60+:

Arthralgia (joint pain)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Viral infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Foot deformity (functional disability of foot)
Keratoacanthoma (a common low-grade (unlikely to metastasize or invade) skin tumour that is believed to originate from the neck of the hair follicle)
Peripheral swelling
Muscular weakness (muscle weakness)
Back pain
Blood urea nitrogen/creatinine ratio increased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 30 people, 54.55%
Asthma: 13 people, 23.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 23.64%
Depression: 11 people, 20.00%
Restless Leg Syndrome (a powerful urge to move your legs): 9 people, 16.36%
Pain: 9 people, 16.36%
Neuralgia (pain in one or more nerves): 8 people, 14.55%
Osteoporosis (bones weak and more likely to break): 7 people, 12.73%
High Blood Cholesterol: 7 people, 12.73%
High Blood Pressure: 5 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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