Enflurane and Nitrous oxide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enflurane (enflurane) and Nitrous oxide (nitrous oxide). Common drug interactions include pulmonary oedema among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Enflurane and Nitrous oxide. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Enflurane?

Enflurane has active ingredients of enflurane. eHealthMe is studying from 150 Enflurane users. Check the latest studies of Enflurane.

What is Nitrous oxide?

Nitrous oxide has active ingredients of nitrous oxide. eHealthMe is studying from 1,780 Nitrous oxide users. Check the latest studies of Nitrous oxide.

On Jul, 26, 2026

16 people who take Enflurane and Nitrous oxide together, and have interactions are studied.

Enflurane and Nitrous oxide drug interactions.

What are the common drug interactions of Enflurane and Nitrous Oxide, by gender? *:

female:

Pulmonary oedema (fluid accumulation in the lungs)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)
Apnoea (suspension of external breathing)
Depressed level of consciousness
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Acidosis (build-up of carbon dioxide in the blood)
Angioedema (rapid swelling of the dermis)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Hypotension (abnormally low blood pressure)

male:

Cardiac arrest
Hypoxia (low oxygen in tissues)
Pulmonary oedema (fluid accumulation in the lungs)
Atrioventricular block complete (heart block complete)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hyperkalaemia (damage to or disease of the kidney)
Hyperthermia (body temperature greatly above normal)
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Ketoacidosis (high concentrations of ketone bodies in blood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Enflurane and Nitrous Oxide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hyperthermia (body temperature greatly above normal)
Ketoacidosis (high concentrations of ketone bodies in blood)

10-19:

Cardiac arrest
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hyperkalaemia (damage to or disease of the kidney)
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

20-29:

n/a

30-39:

Pulmonary oedema (fluid accumulation in the lungs)
Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)
Apnoea (suspension of external breathing)
Depressed level of consciousness
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Atrioventricular block complete (heart block complete)

40-49:

n/a

50-59:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Parkinson's disease
Hypoxia (low oxygen in tissues)

60+:

Acidosis (build-up of carbon dioxide in the blood)
Angioedema (rapid swelling of the dermis)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Nodal arrhythmia (an irregular heart beat originating from within the atrioventricular node)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Pulmonary oedema (fluid accumulation in the lungs)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

What are the existing conditions these people have? *

Anaesthesia: 11 people, 68.75%
Neuromuscular Blockade: 1 person, 6.25%
Hypotonia (low muscle tone): 1 person, 6.25%
Hypokalemia (low potassium): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
Bradycardia (abnormally slow heart action): 1 person, 6.25%
Arrhythmias (irregular heartbeat): 1 person, 6.25%
Acne (skin problems that cause pimples): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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