Entresto and Bentyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Bentyl (dicyclomine hydrochloride). Common drug interactions include blood pressure systolic decreased among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Bentyl. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Bentyl?

Bentyl has active ingredients of dicyclomine hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 10,754 Bentyl users. Check the latest studies of Bentyl.

On Aug, 09, 2026

11 people who take Entresto and Bentyl together, and have interactions are studied.

What are the common drug interactions of Entresto and Bentyl, by gender? *:

female:

Blood pressure systolic decreased
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Abdominal distension
Chronic kidney disease

male:

Hypotension (abnormally low blood pressure)
Cardiac failure congestive
Weight decreased
Constipation
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gait disturbance
Weight increased
Cellulitis (infection under the skin)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Entresto and Bentyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Hypotension (abnormally low blood pressure)
Dyspnoea (difficult or laboured respiration)
Pulmonary oedema (fluid accumulation in the lungs)
Weight decreased
Blood pressure systolic decreased
Constipation
Ejection fraction decreased (systolic heart failure)
Fatigue (feeling of tiredness)
Gait disturbance
Weight increased

What are the existing conditions these people have? *

Cardiac Failure: 3 people, 27.27%
Diabetes: 3 people, 27.27%
High Blood Pressure: 3 people, 27.27%
Gout (uric acid crystals building up in the body): 3 people, 27.27%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
Cardiac Disorder: 2 people, 18.18%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 18.18%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 18.18%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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