Epclusa and Thiamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Thiamine (thiamine (vitamin b1)). Common drug interactions include hepatic encephalopathy among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Thiamine. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Thiamine?

Thiamine has active ingredients of thiamine (vitamin b1). eHealthMe is studying from 11,036 Thiamine users. Check the latest studies of Thiamine.

On Jul, 26, 2026

25 people who take Epclusa and Thiamine together, and have interactions are studied.

What are the common drug interactions of Epclusa and Thiamine, by gender? *:

female:

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypokalaemia (low potassium)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Diabetic coma
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hepatic failure (liver failure)
Hyperglycaemia (high blood sugar)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

male:

Death
Abdominal pain upper
Emotional distress
Joint injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Stomatitis (inflammation of mucous membrane of mouth)
Altered state of consciousness (altered state of mind)
Asthenia (weakness)

What are the common drug interactions of Epclusa and Thiamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Depression
Weight decreased
Death
Anaemia (lack of blood)
Blood bilirubin increased
Infection

50-59:

Blood creatinine increased
Renal impairment (severely reduced kidney function)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Bone density decreased
Confusional state
Death
Diabetes mellitus inadequate control
Emotional distress

60+:

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Asthenia (weakness)
Gait disturbance
General physical health deterioration (weak health status)
Hepatic mass
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Oedema (fluid collection in tissue)
Pancreatic atrophy
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Hepatitis C: 6 people, 24.00%
Muscle Spasms (muscle contraction): 2 people, 8.00%
Hiv Infection: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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