Epidiolex and Prednisolone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epidiolex (cannabidiol) and Prednisolone (prednisolone). Common drug interactions include drug resistance among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Epidiolex and Prednisolone. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Epidiolex?

Epidiolex has active ingredients of cannabidiol. eHealthMe is studying from 18,763 Epidiolex users. Check the latest studies of Epidiolex.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

On Jul, 15, 2026

42 people who take Epidiolex and Prednisolone together, and have interactions are studied.

Epidiolex and Prednisolone drug interactions.

What are the common drug interactions of Epidiolex and Prednisolone, by gender? *:

female:

Drug resistance (reduction in effectiveness of a drug)
Influenza
Nephrolithiasis (calculi in the kidneys)
Pain
Acute respiratory failure
Hepatic failure (liver failure)
Drug ineffective
Multiple-drug resistance

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Acute respiratory failure
Pneumonia
Cardiac arrest
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Hospitalisation
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Epidiolex and Prednisolone, by age (0-1 to 60+)? *:

0-1:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Pneumonia
Drug resistance (reduction in effectiveness of a drug)
Drug ineffective

2-9:

Acute respiratory failure
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cardiac arrest
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Nephrolithiasis (calculi in the kidneys)
Pulse absent
Sepsis syndrome (a clinical condition of blood infection)

10-19:

Acute respiratory failure
Hepatic failure (liver failure)
Hospitalisation
Death

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 16 people, 38.10%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 11 people, 26.19%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 10 people, 23.81%
Idiopathic Generalised Epilepsy (epileptic disorders that are believed to have a strong underlying genetic basis): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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